The molecular formula of lincomycin hydrochloride is c18h34n2o6s. Lincomycin hydrochloride is effective against grampositive bacteria. May 16, 2019 lincomycin lincomycin hydrochloride powder, for solution out of scope out of scope for rxnorm and will not receive rxnorm normal forms. List of drug master files dmf of lincomycin hydrochloride active pharmaceutical ingredient api submitted to the u. Lincomycin hydrochloride, monohydrate msds special notice. Lincomycin is a lincosamide antibiotic derived from bacteria streptomyces lincolnensis with activity against gram positive and anaerobic bacteria. Other requirements where the label states that lincomycin hydrochloride is sterile,it meets the requirements for sterility and bacterial endotoxins under lincomycin injection. The purpose of this study was to evaluate the chemical stability of lincocin lincomycin hydrochloride in commonly used intravenous fluids at room temperature 25.
Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Directions for use lincomycin hydrochloride soluble powder dosage and administration. Find patient medical information for lincomycin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In topical form, clindamycin is becoming very popular among clinical dermatologists. Lincocin has caused rare, but sometimes fatal intestinal problems. Lincomycin hydrochloride soluble powder is indicated for the control of necrotic enteritis caused by clostridium perfringens susceptible to lincomycin. Lincomycin hydrochloride soluble powder for animal use. Do not use in horses intended for human consumption. Lincomycin definition of lincomycin by the free dictionary. P is the designated potency, in g of lincomycin per mg, of usp lincomycin hydrochloride rs. Feb 27, 2019 lincomycin hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor.
In clinical studies, this dose rate provided an average of 3. Pdf stability studies of lincomycin hydrochloride in aqueous. Assessing the depletion of lincomycin in feathers from. In rats and mice, the acute oral ld50 of different pharmacopoeial and premix grades of lincomycin hydrochloride. To reduce the development of drugresistant bacteria and maintain the effectiveness of lincocin and other antibacterial drugs, lincocin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Lincocin lincomycin hcl how suppliedstorage and handling. Lincomycin article about lincomycin by the free dictionary. Safety data sheet lincomycin hydrochloride injection, usp. W is the weight, in mg, of the portion of lincomycin hydrochloride taken to prepare the assay preparation. It has a role as an antimicrobial agent and a bacterial metabolite. It also shouldnt be used to treat nonbacterial infections.
Clindamycin is prepared as the hydrochloride salt of the base in 75, 150, and 300mg capsules and of the palmitate ester as a powder for pediatric suspension 75 mg5 ml. It should be used with caution due to the risk of diarrhoea. Lincocin lincomycin hydrochloride product monograph. Find patient medical information for lincomycin injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Lincomycin is injected into a muscle, or into a vein through an iv. Lincomycin side effects, dosage, interactions drugs. A validated stabilityindicating hplc method for routine. Overall summary of the scientific evaluation of lincocin. Other information text of r phrases mentioned in section 3 r43 may cause sensitization by skin contact. Lincocin lincomycin hcl pfizer medical information us. Cleocin hclclindamycin hydrochloridecapsules, usp page 1. Lincocin products contain lincomycin hydrochloride, an antibiotic produced by. Lincocin sterile solution contains lincomycin hydrochloride which is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of streptomyces lincolnensis fam. Lincocin lincomycin hydrochloride dose, indications. Lincomycin hydrochloride skin irritation guinea pig moderate benzyl alcohol material name. It should be used only in cases where other medicines are less effective. The molecular formula of lincomycin hydrochloride is.
Where the label states that lincomycin hydrochloride must be subjected to further processing during the preparation of injectable dosage forms,it meets the requirements for bacterial endotoxins under lincomycin injection. Jul 02, 2018 lincomycin hydrochloride pharmacokinetics absorption bioavailability. Side effects are rash, itching, nausea, vomiting, and diarrhea. The chemical name for lincomycin hydrochloride is methyl 6,8dideoxy61methyltrans4propyll2. Lincocin lincomycin dosing, indications, interactions. Lincomycin hydrochloride monograph for professionals. Assessing the depletion of lincomycin in feathers from treated broiler chickens. The harmonized system hs code provided on this webpage are for information purposes only and are subject to change without notice. Buy 7epi lincomycin hydrochloride salt cas 26389844, a biochemical for proteomics research, from santa cruz. An antibiotic produced by streptomyces lincolnensis var. Lincomycin hydrochloride w as found to maintain its shelf life at 25c in sodium lactate hartmanns solution, 0. This study reports the development and validation of a simple reverse phase chromatographic method using uv detection for the routine analysis and quality control of the combined spectinomycin and lincomycin injectable formulation which contains the active ingredients. In a glp conforming study, five groups of two pigs received oral doses of c lincomycin hydrochloride of 440 mg per animal per day by capsule hornish. The feces of mice were collected in the control stage day 0, with no treatment, modeling stage day 5, with the inoculation of lincomycin hydrochloride, treatment stage day 10, with the drug treatment, and recovery stage day 17, with no management.
Lincocin lincomycin hydrochloride should be used with caution in those patients with a history of gastrointestinal disease. Lincomycin hydrochloride injection, usp lincomycin hydrochloride rat oral ld50 1230 mgkg 30 days rat oral 300 mgkgday noael no effects at maximum dose rat oral ld 50 4000 mgkg. Each ml containing lincomycin hydrochloride equivalent to lincomycin, 50 mg. Lincomycin inhibits bacterial protein synthesis by forming crosslinks within the peptidyl transferase loop region of the 23s rrna. Topically applied lincomycin for acne jama dermatology. Pdf purpose the purpose of this study was to evaluate the chemical stability of lincocin lincomycin hydrochloride in commonly used. To the monograph and addendum prepared by the 54th and 58th meetings of the committee. Lincomycin is a lincosamide antibiotic that comes from the actinomycete streptomyces lincolnensis. Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids petra czarniak, michael boddy, bruce sunderland, jeff d hughes school of pharmacy, curtin university, perth, wa, australia purpose. Lincomycin binds to the 50s subunit of the bacterial ribosome resulting in the inhibition of protein synthesis and thereby produces bactericidal effects in susceptible organisms. Lincomycin hydrochloride soluble powder indications and usage. Lincomycin is a carbohydratecontaining antibiotic produced by the actinomyces streptomyces lincolnensis. Stability studies of lincomycin hydrochloride in aqueous.
Dailymed lincocin lincomycin hydrochloride injection, solution. Nov 09, 2018 lincomycin is an antibiotic that fights bacteria. Store at controlled room temperature 20 to 25c 68 to 77f see usp. Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding it is produced by streptomyces lincolnensis var. Lincomycin hydrochloride is freely soluble in water. Product monograph prlincocin lincomycin injection usp. The lincomycin hydrochloride market has encountered significant development in the recent years and is anticipated to grow tremendously over the forecast period. Lincomycin first draft prepared by richard ellis, washington. Dailymed lincomycin lincomycin hydrochloride powder, for. Lincomycin hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7hydroxy group with a chlorine atom with inversion of chirality.
Lincocin lincomycin injection, usp to reduce the development of. Clindamycin is a semisynthetic antibiotic produced by a 7schlorosubstitution of the 7rhydroxyl group of the parent compound lincomycin. Lincocin is indicated for the treatment of localized infections, such as abscesses, pneumonitis, and feline rhinotracheitis. Lincomycin hydrochloride soluble powder ireland oel twas 6 mgm3 2.
It is a carbohydratecontaining antibiotic, a sglycosyl compound, a monocarboxylic acid amide, a pyrrolidinecarboxamide and a lproline derivative. Close monitoring of liver and kidney function is necessary while receiving this medicine. Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg or 300 mg of clindamycin. Residue depletion study with 14clabelled lincomycin an equal number of 25 days old male and female hubbardcrosshubbard chicks were given water containing 14clincomycin hydrochloride, equivalent to 34 g of lincomycin free baseml specific activity 2. Lincomycin hydrochloride soluble powder is indicated for the treatment of swine dysentery bloody scours. Lincomycin hydrochloride api dmfs us drug master file. Lincomycin hydrochloride zoetis oel twa 8hr 100gm3 estonia oel twa 2 mgm3 silicon dioxide, colloidal nf finland oel twa 5 mgm3 revision date. Similar discouraging reports regarding topical application of tetracycline in acne turned our attention to two of the few remaining effective antibiotics, lincomycin hydrochloride monohydrate lincocin and clindamycin cleocin. To report adverse effects, access medical information, or obtain additional product. Lincomycin hydrochloride market by product and end user.
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